Humidity control for tablet coating is critical in ensuring a smooth and opaque finish. Tablet coating is a crucial pharmaceutical manufacturing process characterized by high temperatures ranging from 70 to 90°C and a very low dew point between 0 to -10°C.
In the coating pan for tablets, heavy sugar solution is added to the tumbling mass during the tablet coating process. As the water evaporates, sugar crystals cover each piece. Blowing the proper quantity of air at the correct dry and wet bulb temperatures forms a smooth, opaque coating. If cooling and drying are not at the desired rate, the coating gets rough, translucent, and unsatisfactory in appearance; if too fast, the coating chips through to the interior.
Impact of Uncontrolled Temperature and Dew Point
Inadequate dry air during the coating process can give rise to a pitting problem, ultimately affecting the aesthetic quality of the tablets. Pitting manifests as small depressions or imperfections on the tablet surface, compromising its smooth and glossy appearance. Precise control of temperature and dew point is extremely important in preventing this issue.
Besides, uncontrolled temperature and dew point during tablet coating can lead to significant defects in the final product. Without proper humidity control for tablet coating, high temperatures may cause the coating solution to evaporate too quickly, resulting in rough, uneven surfaces and potential chipping. On the other hand, a low dew point without adequate humidity control for tablet coating can lead to slow drying, causing the coating to become sticky, rough, or translucent. These defects not only compromise the tablet’s appearance but also its efficacy and shelf life. Effective humidity control ensures consistent coating quality, preventing these issues and maintaining product integrity.
Recommendation
Ensuring the recommended temperature and dew point parameters are essential for the overall quality of the final pharmaceutical product. This will guarantee not only visual appeal but also the effectiveness and stability of the medication.
| Application |
Temperature |
Dew Point (°C) |
| °C |
°F |
| Tablet Coating |
70 – 90 |
158 – 194 |
0 – (-) 10 |
Bry-Air Solution
Bry-Air Desiccant dehumidifiers can maintain RH as low as 1% or even lower at constant level, regardless of ambient conditions. These dehumidifiers are CNC fabricated with powder coated finish incorporating high performance Metal Silicate Fluted media, which is bacteria static, non-toxic and thus, ideal to meet GMP requirements of the pharmaceutical industry.
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