The filling operations include conveying of powdered substances to packaging areas in a high velocity air-stream and filling minute quantities of the powder in the vials and capsules. High humidity may cause the powder to stick and cluster together in the conveyor thus hampering airveying and filling operations. It pose challenges by affecting the powder’s flow characteristics, leading to inconsistent filling and dosing.
This can result in inaccurate drug quantities per vial, jeopardizing product quality and increasing the chances of rejection. Moreover, humidity can cause powder clumping, leading to equipment blockages and downtime.
Some Common Sources of Moisture
- Head-space, i.e., the air enclosed within the package during production
- The initial water content of the product
The presence of moisture in the filling environment also poses a risk of microbial contamination, threatening product sterility. Moisture can accelerate the degradation of sensitive pharmaceutical ingredients, reducing the shelf life of the final product. Additionally, humidity-induced variations in vial filling may lead to difficulties in meeting regulatory standards, potentially resulting in compliance issues.
General Recommendation
| Application |
Temperature |
Humidity
% RH |
| °C |
°F |
| Dry Powder / Vial Filling |
25 |
77 |
20-25 |
The Bry-Air Solution
Dehumidification or Moisture/ Humidity Control solutions are almost essential across all the various stages and processes of the Pharmaceutical Industry, including the dry powder/ vial filling process.
Bry-Air Desiccant dehumidifiers can maintain RH as low as 1% or even lower at constant level, regardless of ambient conditions. Bry-Air dehumidifiers are CNC fabricated with powder coated finish incorporating high performance Metal Silicate Fluted media, which is bacteria static, non-toxic and thus, ideal to meet GMP requirements of the pharmaceutical industry.
Installing Bry-Air Dehumidifiers at the dry powder/ vial filling area will help you by:
- Eliminating the chances of forming lumps formation
- Ensuring free flow of powder
- Maintaining the exact quantity per vial, reducing rejection chances
- Avoiding any biological damage or decomposition of the product
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